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Microbiota-derived metabolites are key mediators of host-microbe interactions ( 2.3 Bidirectional neuroendocrine crosstalk In addition to regulating host metabolism and immune responses, the gut microbiota is recognized to play a critical role in the production of neurotransmitters and engages in complex bidirectional communication with the hypothalamicpituitarygonadal (HPG) axis, contributing significantly to the pathogenesis and potential treatment of PCOS

Study has shown that Nrf2 is highly expressed in cancer tissues of NSCLC patients and can regulate the sensitivity of NSCLC cells to ferroptosis induced by Cys 2 deprivation [88]

SAS Institute, Cary, NC, USA) and MSTAT-C software 35 (Freed and Scott 1989)

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