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Current challenges facing the research field and outstanding questions remaining to be answered are identified below: Reliable and reproducible measurement of ROS-induced macromolecular damage relevant to carcinogenesis remains, at least partly, an analytical challenge, especially when different methods and non-harmonized bench protocols in various laboratories are employed

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The term sophisticated applies not to product complexity but to the understanding that genuine satisfaction can exist at lower intensity levels when tobacco selection and filtration engineering are executed properly