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10.1523/JNEUROSCI.3968-04.2004 150 YangC.WangC.WangM.QinX.HaoG.KangM.et al (2021)

3 Once activated by infection, neutrophils are rapidly recruited to sites of inflammation in the lungs, where they produce and secrete cytokines, enzymes, including elastase (NE), reactive oxygen species (ROS) by oxidative burst, and finally release DNA to form neutrophil extracellular traps (NETs)

To break through this bottleneck, a combined intervention strategy has emerged: Shikonin (SHK) and curcumin (CUR) form a self-delivering nanosystem (chitosan-polyethylene glycol nanoparticles, CS-PEG NPs) that synergistically induces endoplasmic reticulum stress and Ca 2+ homeostasis imbalance, which significantly increases the release of DAMPs, thereby increasing DC maturation and significantly increasing the infiltration density of CTLs in the core region of the tumor (from 5% to 20%) (211), Thus reversing the immunosuppression mediated by regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs)

Despite promising evidence, important gaps remain