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The recent phase 2, placebo-controlled PANORAMA trial was designed to assess the safety and tolerability of NAC combined with pirfenidone in patients with IPF (n = 123) [32]

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If a trial is recommended, use low doses and close observation, and stop immediately if seizures occur or worsen

ER zinc dysregulation The ER is highly sensitive to perturbations in zinc homeostasis, and disturbances in luminal or cytosolic zinc can initiate maladaptive stress responses that contribute directly to human disease