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Fluctuations in ovarian hormones, particularly estradiol and progesterone, may contribute to these sex-specific patterns, as both hormones are known to modulate immune activity and influence KP metabolite levels [55]

Sealing the gut can help downregulate the overactive immune response, often leading to a reduction in autoimmune symptoms and flare-ups

This is because of the observed risk for myocarditis and pericarditis after receipt of ACAM2000 orthopoxvirus vaccine and COVID-19 vaccines, and the hypothetical risk for myocarditis and pericarditis after Jynneos vaccine

The mean age of the participants was 309 years and 69.4% were male