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2008;101(S3):2-6

76,115 On the contrary, damaged mitophagy gives rise to mitochondrial ROS increase and mitochondrial damage, leading to cell damage and even cell death

Computational approaches, including AI-based network pharmacology, may help identify multi-target interactions and guide experimental validation in advanced models such as organoids and patient-derived xenografts

3.2 Morphology and growth characteristics of PDX over several in vivo passages Our established GBM PDX models closely resemble the respective patients tumor histology, with similar morphology and expression patterns of MGMT and Ki-67 ( Figure 1A )