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How We Got Here: Origins and Naming Both molecules trace back to melanocortin research aimed at a tan without UV as a way to reduce skin-cancer risk from sun exposure

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Chin Med J (Engl) 2004

3.10 Traumatic brain injury and stroke Traumatic brain injury (TBI) and ischemic stroke are common acute central nervous system injuries that share a characteristic cascade: following the initial mechanical or perfusion insult, mitochondrial dysfunction ensues, leading to excessive reactive oxygen species (ROS) production, calcium overload, and neuronal apoptosis