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During a follow-up of 7 or 12 years (depending on the time of survey), the risk ratios in men and women were 1.45 and 1.48 for total stroke and 1.51 and 1.59 for ischemic stroke (calculated per unit increase in log GGT)

Together these observations suggest that not just any degeneration of myelin, but a specific modification of its constituents is required to elicit a secondary adaptive immune response