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Renal impairment reduces B12 excretion, leading to accumulation

Evidence type: Human RCT | Observational | Animal | In vitro | Regulatory Mechanism of Action 5-Amino-1MQ works by blocking the NNMT enzyme , which is responsible for consuming nicotinamide and depleting NAD+ stores

The enzyme is found primarily in mast cells, neurons, basophils, and cells lining the stomach.[ref] Genetic variants in the HDC gene affect the susceptibility to Tourettes syndrome and heart disease