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Some of these interactions involve the upregulation of CD38, mediated by adipocyte-secreted angiotensin II (Ang II), which has been identified as the direct cause of increased expression of acetyl-CoA synthetase (ACSS2) in MM plasma cells, promoting growth by stabilizing the oncoprotein IRF4 in vitro and in vivo (95)

PubMed: 17332148 AOD 9604 Versus Placebo in Obese Adults: A 52-Week Randomized, Double-Blind Extension Study human rct Hefti FF, Hefti F, Lichtensteiger W, et al