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Medications and Glucose-6-Phosphate Dehydrogenase Deficiency An Evidence-Based Review Ilan Youngster Lidia Arcavi Renata Schechmaster Yulia Akayzen Hen Popliski Janna Shimonov Svetlana Beig Matitiahu Berkovitch Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect and one of the most common genetic disorders worldwide, with an estimated 400 million people worldwide carrying a mutation in the G6PD gene that causes deficiency of the enzyme

Mechanism of Action Acetyl Group Protection : The acetyl modification acts as a molecular shield that helps protect glutathione from degrading enzymes in your digestive tract, blood plasma, and extracellular spaces

doi:10.1016/j.autrev.2009.02.020 Perrone GG, Dawes IW, Grant CM (2005) Glutathione production

Low doses of paracetamol are safe because they are eliminated mainly by conjugation, and any NAPQI created by cytochrome P450 oxidation is inactivated by a cytoprotective pathway involving glutathione