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Disclosures: Daniel Yan Zheng Lim: Nothing to Disclose, Siyuan Yin: Nothing to Disclose, Charlene Tan Hui Ru: Nothing to Disclose, Jeanette Ng: Nothing to Disclose, Chee-Kiat Tan: Eisai: Advisor, Abbott Laboratories: Advisor, Gilead Sciences: Advisor, Roche Diagnostics: Advisor, Fujifilm: Advisor, George Boon Bee Goh: Nothing to Disclose 2066 MULTIPLEXED IN VIVO SCREENING REVEALS THE DELETERIOUS EFFECTS OF FIBROGENIC FACTORS ON HEPATOCYTES Joanne Hsieh 1 Vinay Kartha 1 Hikaru Miyazaki 1 Christopher Carrico 1 Linda Chio 1 Daniel Fuentes 1 Dimitry Popov 1 Ian Driver 1 Chris Towne 1 Francisco LePort 1 Martin Borch Jensen 1 , 1 Gordian Biotechnology Background: Hepatocyte injury and death promotes fibrosis deposition, but the ramifications of extracellular matrix composition on hepatocytes is less understood

The peptides development was ultimately discontinued in 2007 after a 24-week Phase III trial failed to demonstrate statistically significant weight loss compared to placebo, though research into its regenerative properties has continued

TJs comprised transmembrane proteins such as occludins and claudins and peripheral membrane proteins such as ZO (zonula occludens proteins) [31]