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Borkent, J., Ioannou, M., Laman, J

Instead, despite partial compensatory mechanisms, meta-inflammation sustains a self-reinforcing loop between stress signaling and insulin-pathway inhibition, promotes IR and endothelial dysfunction (endotheliosis), andunder hyperinflammatory conditionsmay progress toward overt endotheliitis, thereby contributing to cardiovascular disease and other T2DM complications