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Compounds spanning 100-fold IC50 values for NNMT inhibition were selected on the basis of positional substitutions around the N-methylated quinolinium scaffold to obtain an estimate of drug-like oral absorption/bioavailability properties and guide the choice of inhibitors for in vitro and in vivo phenotypic studies

it fundamentally changes the biological environment to allow for true, intrinsic repair

For detailed cell counts in other time points (in cells/mm 2 ): 1w (CPZ,126.6512.65 vs

This roadblock for basic research and preclinical development is circumvented by studying closely related betaherpesviruses such as mouse cytomegalovirus (MCMV