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453 Emerging evidence indicates that exogenous stimuli, including fungal components, may drive and perpetuate immunosenescence

Funding This work was supported by the grants from Karolinska Institutet

BENEFITS Tissue repair studied for accelerating recovery in tendon, ligament, and muscle models Gut protection explored for protective effects on gastric and intestinal lining Angiogenesis linked to promotion of new blood vessel formation in healing tissues Anti-inflammatory associated with reduction of inflammatory markers in preclinical research Neuroprotection investigated for potential nerve regeneration pathways WHAT RESEARCHERS LOOK AT Angiogenesis and vascularization in connective tissue recovery Fibroblast migration and collagen deposition pathways Gastric and intestinal lining protection in animal models Neuroprotective and anti-inflammatory signaling cascades Synergistic effects when combined with TB-500 (Thymosin Beta-4)

The model also implicated alterations in the glycosylated extracellular matrix through the proteins tenascin R (TNR), neurocan (NCAN) and heparan sulfate-glucosamine 3-sulfotransferase 4 (HS3ST4), underlining the role of the extracellular matrix in brain aging