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We tested whether COP1 or DDD-COP1 directly interacts with p53 using co-expression and pull-down assays in human cells, and found no detectable interaction under the conditions tested (Supplementary Fig

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Ivermectin solution was added slowly into the mixture of chitosan-selenium NCJ to prepare the nanoconjugate of IVM at a concentration of 0.5% w/v

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The energetically best cluster complex structure was next used for refinement and dynamic analysis

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