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Man-made liver organoids also fail to experience APAP-induced necrosis to date because of loss of most CYP2E1 expression as the cultures grow over the extended time required for organoid formation

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Lysosomal escape BEAS-2B cells were inoculated in 24-well plates at 8 10 4 cells/well and cultured for 24 h

Am Fam Physician 76:3916 Wu Y, Zhang X, Bardag-Gorce F, Robel RC, Aguilo J, Chen L, Zeng Y, Hwang K, French SW, Lu SC, Wan YJ (2004) Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver