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22,23,24 The inflammation from endotoxins shuts down key detoxification transporters and enzymes in the liver25,26,27,28, that normally prevent bacterial and dietary antigens from entering systemic circulation.29 This ongoing inflammation further increases susceptibility to toxins and xenobiotics.30 Binderswhich increase enterosorptionare therefore a key strategy in downregulating inflammation and facilitating detoxification, both daily and in more intensive, focused regimens

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Naunyn Schmiedebergs Arch Pharmacol 393:325337 Vincenzi B, Armento G, Spalato Ceruso M et al (2016) Drug-induced hepatotoxicity in cancer patients-implication for treatment