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Symptoms of B12 Deficiency Symptoms of B12 deficiency can vary, but may include one or more of the following: Depression Irritability Poor memory Lethargy Fatigue Feeling faint Heart palpitations Shortness of breath Balance problems Vision changes Pins & needles Headaches Sore, swollen tongue Mouth ulcers Constipation Benefits of Vitamin B12 Our bodies require vitamin B12, which is also essential for the healthy operation of the neurological system and the brain