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Introduction Iatrogenic withdrawal syndrome (IWS) refers to the development of withdrawal symptoms when the causative agents (i.e., sedative or analgesic) are abruptly discontinued or rapidly tapered in critically ill patients

Abstract Parkinsons disease (PD), the second most common neurodegenerative disorder worldwide, features gradual loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) along with pathological -synuclein (-syn) aggregation