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In vivo evidence for the role of choline metabolism in RA comes from studies using the K/BxN serum-transfer mouse model of inflammatory arthritis, where treatment with the choline kinase alpha (ChoK) inhibitor MN58b (3 mg/kg) prevented disease onset ( Other recent studies have investigated the lipidomic profile of arthritis patients in different phases of the disease to understand the correlation between lipid alteration and the severity of local inflammation (188190)

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