cd38 inhibitor benefits with 5-amino-1mq blocks an enzyme called NNMT, and the mechanism is real, but NNMT overexpression does not track body fat. It tracks insulin resistance. Non-diabetic individuals at BMI 33 had normal NNMT. And Frontiers | Monoclonal anti-CD38 therapy
Frontiers Monoclonal anti CD38 therapy in human myeloma: retrospects and prospects Biological Functions and Therapeutic Potential of NAD+ Metabolism in Gynecological Cancers Frontiers Nicotinamide N methyltransferase (NNMT): a novel therapeutic target for metabolic syndrome Anti CD38 antibody therapy for patients with relapsed refractory multiple myeloma: differential mechanisms of action and recent clinical trial outcomes Annals of Hematology Springer Nature Link
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