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Primary endpoints should center on pain and function Knee Injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Patient-Reported Outcome Measurement Information System (PROMIS) scores), structure (MRI evaluation with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) when appropriate), and time to milestones (return to sport)

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And even as GLP-1 injectables have become more common, the idea of giving yourself an injection can still feel intimidating or overwhelmingespecially at first

Their mechanisms of action are completely different, focusing on cellular repair and signaling pathways