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Some major drawbacks associated with the clinical application of such NPs are their poor ability to cross the BBB and the inconsistent clinical efficacy of GDNF in PD treatment

Treatment with artemisinin, an anti-malarial drug with immune-regulatory and anti-tumor effects, synergizes with anti-PD-L1 therapy in melanoma tumor models, inhibiting MDSC immunosuppression and accumulation and promoting T cell anti-tumor effects (162)

Some can be run concurrently and some cannot

Melatonin supplementation enhances mitochondrial dynamics and bioenergetics to support and elevate ATP production Conclusions The unknown long-term health and social-economic impact of Neuro-PASC remains a major concern and potential burden for society in the post-pandemic era