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This work was supported by the National Natural Science Foundation of China (32170119) and Funded by CMC Excellent-Talent Program (2024kjTzn01)

Full pathway activation may represent the core metabolic strategy employed by tumor cells to cope with environmental stress and sustain malignant phenotypes

[7] Gu Z, Shi C, Li J, et al. Palbociclib-based high-throughput combination drug screening identifies synergistic therapeutic options in HPV-negative head and neck squamous cell carcinoma. BMC Med. 2022;20(1):175. Published 2022 May 12. doi:10.1186/s12916-022-02373-6(IF:8.775)

Interestingly, a randomized double-blind phase III clinical trial to evaluate elesclomol in combination with chemotherapy in patients with melanoma showed that elesclomol had stronger anti-tumor activity in patients with low plasma levels of lactate dehydrogenase 205 (Table 1)