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Vitamin C synthesis, absorption, accumulation, and excretion follow a complex biochemical pathway converting glucose into glucuronic acid, a key metabolite for detoxification and metabolic regulation

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Furthermore, they observed a strong negative correlation between TRAP values and high plasma ascorbic acid levels in CF patients, suggesting that high concentrations of ascorbic acid might exert a pro-oxidant effect in the context of CF, thereby diminishing the overall extracellular antioxidant defense (Langley et al., 1993)