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If the pain is refractory to those treatments, the use of intravenous ketamine in infusion has recently been described as an option.117119 In addition, enabling the patient to rest in a quiet and darkened environment and maintaining good hydration with crystalloid solutions, even when the patient shows no signs of dehydration, appear to be beneficial

Methods: C57BL/6 mice were treated with CCl 4 for 16 wks to induce Type C HE and received a senolytic cocktail of dasatinib and qercertin (D/Q via oral gavage) starting after 8 wks of CCl 4 injections