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As the cellular stress intensifies, the expression of autophagy-related proteins surges once more, reinforcing the cells efforts to degrade and recycle cellular components

PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega- O -acylceramide synthesis and skin permeability barrier

Kozlovskaya, L., Abou-Kaoud, M

Together, these results mean that the metabolites of gut microbiota disturb regulation of joint FTN and homeostasis of iron, thereby may inducing iron overload that triggers ferroptosis and accelerate the development of OA