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However, many clinicians and some researchers feel there is a large grey zone between 160-500 pmol/L, which in some patients could represent functional deficiency on a cellular level

Where Phase I or Phase II human trials exist, they are noted in the compound page summary

Better sleep doesnt replace B12, but it can reduce the sense that treatment isnt working

Generally, these new strategies should be directed towards diseases with significant unmet clinical needs, including cases that have relapsed or are resistant to current treatments, as well as rare (orphan) diseases