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Additionally, by upregulating the anti-apoptotic cell lymphoma extra-large (Bcl-xL) and downregulating the BCL2-linked X-protein, hesperidin as an apoptosis regulator successfully modulated the expressions of apoptosis regulatory proteins (Bax) [429]

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Other observations show that diabetes and hyperglycemia alter the human gut microbiome and induce intestinal barrier dysfunction and enhance the risk for infections (15)

doi: 10.3389/fceld.2023.1219672 Received 09 May 2023 Accepted 27 July 2023 Published 29 August 2023 Volume 2 - 2023 Edited by Chao Chieh Lin, Duke University, United States Reviewed by Jennifer Watts, Washington State University, United States Yasaman Setayeshpour, Duke University, United States Updates Copyright 2023 Cuvelier, Vermonden, Rousseau, Feron, Rezsohazy and Larondelle