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Strategies aimed at reducing high glucose levels by employing sodium-glucose cotransporter-2 inhibitors (SGLT2i) have been shown to significantly lessen the onset of cellular senescence, potentially attributed to the synthesis of -hydroxybutyrate ( Telomere shortening is a widely recognized occurrence in both type 1 and type 2 diabetes, and this process may be hastened by factors such as inflammation, hyperglycemia, glycation end products, and persistent oxidative stress (Sutanto et al., 2019

The notable feature of resulting metal complexes of certain flavonoids is that their scavenging potencies toward superoxide are significantly higher than those of the parent flavonoids (Table 3)

This pharmaceutical-grade formulation ensures rapid and efficient absorption, making it an ideal choice for individuals with B12 deficiency, those following a plant-based diet, or those needing enhanced metabolic support

All the three indexes showed a significant decrease after theaflavins intervention, with the effect of the theaflavins-treated group being more pronounced in the HO-1 knockdown cells compared to normal cells (Fig