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REDEFINE 1 adults with overweight/obesity, no diabetes GI adverse events were reported in 79.6% of CagriSema participants vs 39.9% on placebo

Meta-analysis of expression of hepatic organic anion-transporting polypeptide (OATP) transporters in cellular systems relative to human liver tissue

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The lethal dose threshold (LD1) was never achieved in animal safety studies meaning researchers could not identify a dose lethal to 1% of test subjects