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While both acetaldehyde and methylglyoxal produced cytotoxicity in the MTT assay, methylglyoxal was effective at a much lower concentration (IC 50 for acetaldehyde = 8260 M and IC 50 for methylglyoxal = 262 M) (Figure 6C)

Propylene glycol and glycerin what electronic cigarette liquids dissolve the nicotine in are toxic to cells in the lung, and that addition of commonly used flavoring chemicals increases the toxicity to lung cells