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Acknowledgements The authors thank the Taiwan Health Promotion Administration for collecting the data and providing access to their database for this study Funding The work was supported by the Health Promotion Administration, Ministry of Health and Welfare, Taiwan (Grant Number: MOHW105-HPA-H-114-133708), from Taiwans Health and Welfare Surcharge on Tobacco ProductsGrant Number: 03724606Project Code: 1051218-107), and grants R01DA043950 from the US National Institute of Drug Abuse and P50CA180890 from the US National Cancer Institute, and the US Food and Drug Administration (FDA) Center for Tobacco Products

RESULTS We utilized single nucleotide polymorphisms (SNPs) as genetic instruments for irritability, smoking status, and bipolar disorder, identifying 29, 37, and 91 SNPs, respectively, after the screening process, as detailed in Table 1

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Kurup VP, Resnick A, Kagen SL, Cohen SH, Fink JN (1983) Allergenic fungi and Actinomycetes in smoking materials and their health implications