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Pre-clinical studies showed that although the primary route of NH130 elimination is metabolic, with excretion occurring in metabolites, these metabolites have no therapeutic activity and negligible toxic effects

The plaque formation process promotes the cooperation of iron and lipid accumulation in macrophages, which lead to the development of AS (70)

doi: 10.1016/j.scib.2023.06.003

Our caseoccurring after PD-1 inhibition and in the setting of postoperative pneumonia and HPA-axis activationhad a latency of approximately 10 days, consistent with a primary drug-specific hypersensitivity response but within a complex perioperative immune environment