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Tetrahedral DNA nanostructures (TDNs) as carriers loaded with antioxidant EGCG can efficiently penetrate the biological barrier, sustained release of drugs and antioxidant effects, and significantly improve the noise-induced hearing loss, which provides a novel delivery system for the treatment of inner ear diseases ( Different types of polyphenols may have different mechanisms in preventing cisplatin ototoxicity, and may act synergistically in enhancing its anticancer activity to reduce side effects.EGCG has antioxidant, anti-inflammatory, and inhibitory effects on Caspase-1 and NF-B, and curcumin regulates the Bcl-2/BAX ratio, inhibits the mitochondrial apoptotic pathway, and reduces Caspase-3 activation

However, the levels of therapeutic KBs and the specific effects of each ketone body have not been clearly elucidated

Notably, AgNPs coated with PVP exhibited significantly greater biofilm inhibition compared to those stabilized with EC

Briefly, cells were sequentially treated with the medium containing 25 M of CldU (Sigma-Aldrich, C6891) and then 250 M of IdU (Sigma-Aldrich, I7125) for 20 min