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FIGURE 2 Further research suggests that resistance mechanisms to AmB in Leishmania involve complex interactions between genetic mutations and metabolic changes

At week 20, bodyweight reductions were observed to be greater with cagrilintide 1.2 and 2.4 mg than with placebo (15.7% for cagrilintide 1.2 mg and 17.1% for cagrilintide 2.4 mg vs

TMAO also decreases the mRNA expression of Niemann-Pick C1 (NPC1L1) and ATP-binding cassette (ABC) G5/G8, inhibiting intestinal CHO absorption (Koeth et al., 2013)