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In this study, by establishing and utilizing a revSC-rich organoid culture system, together with detailed isolation of defined cell populations by FACS, we provide experimental evidence demonstrating the high fetal reversion potential of CBCs and the bidirectional interconversion between CBCs and revSCs

(2010) Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide

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Interestingly, the analysis of the tumors by immunoblot revealed decreased levels of galectin-1 and a subsequent elevated levels of granzyme B in tumors that were treated with the combination of sertraline and irradiation ( p = 0.047, p = 0.016, respectively) (Fig