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By comparison, the FDA has authorized only 45 vaping products in its entire history

Of note, there are 2 rarer forms of ichthyosis that also affect filaggrin metabolism, caused by recessive pathogenic variants in CASP1415 and dominant pathogenic variants in ASPRV1.16 While the first form exhibits a phenotype similar to IV, the second one, exceptionally, exhibits a phenotype similar to lamellar ichthyosissee belowbut with palmar hyperlinearity and no collodion membrane at birth.16 Recessive X-linked ichthyosis (RXLI) RXLI affects only men (with a prevalence of 1 in 5000)17 as it is caused by deletions of the steroid sulfatase gene (STS), located in a distal region of the short arm of the X chromosome that does not undergo inactivation.18 Although women are carriers of the disease and transmit it, they only manifest it in the rare cases in which the gene deletion occurs in both chromosomes.19 RXLI is characterized by the presence of dark brown polygonal scales on the extensor surfaces of the extremities (Fig

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