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In aged AD model mice, tau is overexpressed, the cerebral microvessels are disrupted, and abnormal malformed vascular masses form, and cortical atrophy occurs (234)

The urine samples were centrifuged at 4C, 1,000 g for 20 min to obtain the supernatant and the concentrations of urinary albumin and creatinine were determined using a mouse Mau ELISA kit (Wuhan Elabscience Biotechnology Co., Ltd

10.1016/j.ejphar.2006.06.025