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L'absence de comparaison au placebo affaiblit substantiellement la valeur probante de cette observation

A remaining question is whether the decreased FAO is a specific process or reflects a general impairment in mitochondrial function, which needs to be clearly established vis--vis the species-dependent alterations in mitochondrial function in ALD [113], and the opposing outcome of mitochondrial dysfunction between experimental models and patients with MASLD (see below)