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Riboflavin and reproductive health Modulation of hormonal fluctuations and impact on fertility Apart from its role in systemic and vaginal health, riboflavin also seems to impact reproductive health, in part through its reciprocal interaction with estradiol, the most prominent female sex hormone essential for fertility and pregnancy 68,86

GSH depletion through cysteine starvation results in the loss of GPX4 activity, as well as the accumulation of unrepaired lipid peroxides and iron toxicity (Angeli et al., 2018)

Inhibition of CTL1 or ChoK can reduce IL-1 dependent acute inflammation by stimulating mitophagy [60]

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