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When oxidative DNA damage persists, it can lead to the activation of cell-death pathways such as apoptosis, which is a programmed cell-death process [83,131,132]

An example of an epidemic of porphyria cutanea tarda produced by accidental ingestion of wheat treated with the fungicide hexachlorobenzene occurred in Turkey in the 1950s

In the regeneration stage, the fibroblasts (the cells that build the fibers of the connective tissues) proliferate and produce collagens and glycoproteins to form the new tissues