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Simeprevir plus sofosbuvir (12 and 8 weeks) in HCV genotype 1-infected patients without cirrhosis: OPTIMIST-1, a phase 3, randomized study

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Hence according to Apel and Hirt (2004) and Cuypers et al

Since oxidative damage is essential for bortezomib-mediated cytotoxicity, drug resistance may be accompanied by increased tolerance towards oxidative insults