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People with kidney disorders should exercise particular caution with magnesium supplements due to the kidneys' reduced ability to excrete excess magnesium

It was also identified that in the identical subfamily the motif distribution of members was extremely conservative, such as subfamily I members had motifs 7,3 1,8, 2, 5, 4, 10, and 6

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Persistent high levels, particularly without supplementation, may warrant further investigation to rule out medical conditions