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A double-blind RCT (n=33) evaluating the effects of oral coenzyme Q10 on the skin found improvements in wrinkles and skin smoothness, but no changes in skin hydration, dermal thickness, or minimal erythema dose.46 Another double-blind RCT (n=34) found that a dietary supplement containing coenzyme Q10, oral collagen, vitamin C, vitamin A, and biotin for 12 weeks reduced facial wrinkles and increased dermal density, but had no impact on skin hydration or thickness.47 Oral Glucosamine Oral glucosamine sulfate is widely used in osteoarthritis

Given that the degradation of KEAP1 encompasses two distinct pathways, namely autophagy 29 and proteasomal degradation 30 , we employed the protein synthesis inhibitor cycloheximide (CHX), the proteasome inhibitor MG132, and the autophagy inhibitor chloroquine (Chlq) to further explore the underlying mechanism in macrophages (Fig