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This book chapter highlighted the latest findings that support the theory of synaptic dysfunction in BD, providing an overview of the alterations in neurotransmitters release, astrocytic uptake, and receptor signaling, as well as the role of inflammation on glial cells in mood disorders

The process by which SHMT inhibition occurs as a result of PTX exposure was successfully identified in vitro, a finding that emerged through the employment of human recombinant proteins [159]

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