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doi: 10.2139/ssrn.3646583 69 VajaR.ChanJ

Tunyasuvunakool, K., Adler, J., Wu, Z., Green, T., Zielinski, M., dek, A., Bridgland, A., Cowie, A., Meyer, C., Laydon, A., Velankar, S., Kleywegt, G

15 ), causes ( R )-2HG levels to fall, derepressing BCAT enzymes and reestablishing a balance between branched-chain amino acids and glutamine as nitrogen donors to glutamate

These strategies include ROS-inducing strategies like pro-oxidant therapy, mitochondria-targeted ROS generators, inhibitors of antioxidant defense, synthetic antioxidants, and targeting ROS-driven inflammation [81]