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Additionally, the Papot group developed a prodrug by combining a galactoside trigger with a folate receptor (FR) ligand, resulting in the tubulin inhibitor monomethyl auristatin E (MMAE) release (Legigan et al., 2012)

The method of reducing the single dose with the same total dose can make pharmacokinetics safer, lower trough concentration, and reduce the accumulation of cisplatin in the inner ear ( Pedmark, a sodium thiosulfate (STS) formulation, is the first and only novel drug approved by the US FDA to prevent the risk of cisplatin ototoxicity in children aged 1 month and older with localized non-metastatic solid tumors

Synnott NC, Madden SF, Bykov VJN, Crown J, Wiman KG, Duffy MJ