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Pyruvate dehydrogenase (PDH) promotes the transportation of pyruvate into mitochondria, where it is converted to acetyl-CoA [111,112,113,114]

M.Noto LlanaM.PfrtnerH.NiemannS.et al

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While failure of these compensatory mechanisms could ultimately cause ferroptotic cell death, more subtle changes in intracellular redox balance could also enhance signaling pathways, including those associated with T2 inflammation (10)